LSD alters eyes-closed functional connectivity and increases global communication

Record summary

Tagliazucchi and colleagues studied resting-state brain connectivity after LSD, reporting changes that included greater global communication under eyes-closed conditions. The paper is relevant to altered-state comparison because it connects a classic psychedelic’s phenomenology with large-scale network organization rather than a single localized brain area. Its interpretation remains constrained by a small, selected sample and pharmacological confounds. Verify the dose, placebo-controlled design, imaging preprocessing and whether later papers used independent participants or reanalyzed the same scans.